Listing includes: Movie title, Hero's character name (Actor)
- Madame Curie, Madame Curie (Greer Garson), Pierre Curie (Walter Pidgeon), Buy the movie
- The Manhattan Project, Dr. John Mathewson (John Lithgow), Buy the movie
- Mars Attacks!, Prof. Donald Kessler (Pierce Brosnan), Buy the movie
- The Matrix, Neo (Keanu Reeves), Buy the movie
- The Matrix Reloaded, Neo (Keanu Reeves), Buy the movie
- The Matrix Revolutions, Neo (Keanu Reeves), Buy the movie
- Meteor, Dr. Paul Bradley (Sean Connery), Buy the movie
- Metropolis, C. A. Rotwang (Rudolf Klein-Rogge), Buy the movie
- Mimic, Dr. Susan Tyler (Mira Sorvino), Dr. Peter Mann (Jeremy Northam), Buy the movie
- Monsters vs Aliens, Dr. Cockroach PhD, (Hugh Laurie)
- The Muppet Movie, Dr. Bunsen Honeydew (himself), Buy the movie
- The Muppet Christmas Carol, Dr. Bunsen Honeydew (himself), Buy the movie
- The Nutty Professor (1963) Prof. Julius Kelp (Jerry Lewis), Buy the movie
- The Nutty Professor (1996) Sherman Klump (Eddie Murphy), Buy the movie
- Oceans 11, Basher Tarr (Don Cheadle), Buy the movie
- Oceans 12, Basher Tarr (Don Cheadle), Buy the movie
- Oceans 13, Basher Tarr (Don Cheadle), Buy the movie
- Orca, Rachel Bedford (Charlotte Rampling), Buy the movie
- Outbreak, Col. Sam Daniels (Dustin Hoffman), Robby Keogh (Rene Russo), Maj. Casey Schuler (Kevin Spacey), Buy the movie
- Pandorum, Bower (Ben Foster) Payton (Dennis Quaid),
- Panic in the Streets, Lt. Cmdr. Clinton Reed M.D. (Richard Widmark), Buy the movie
- Paycheck, Jennings (Ben Affleck), Rachel (Uma Thurman) Buy the movie
- Proof, Catherine (Gwynneth Paltrow), Robert (Anthony Hopkins), Hal (Jake Gyllenhaal), Buy the movie
- The Puppet Masters, Mary Sefton (Julie Warner), Buy the movie
- Race to Witch Mountain, Dr. Alex Friedman (Carla Gugino)
- Real Genius, Chris Knight (Val Kilmer), Mitch Taylor) Gabriel Jarret), Jordan Cochran (Michele Meyrink). Villain: Prof. Jerry Hathaway (William Atherton), Buy the movie
- Red Planet, Dr. Quinn Burchenal (Tom Sizemore), Buy the movie
- The Rock, Dr. Stanley Goodspeed (Nicolas Cage), Buy the movie
- The Saint, Dr. Emma Russell (Elizabeth Shue), Buy the movie
- The Sixth Day, Michael Drucker (Tony Goldwyn), Buy the movie
- Sky Captain and the World of Tomorrow, Dex (Giovanni Ribisi. Villain: Dr. Totenkopf (Laurence Olivier), Buy the movie
- Spider-Man 2, Villain/Hero Doc Ock/Dr. Otto Octavius), Alfred Molina, Buy the movie
- Spider-Man 3 D. Connors (Nathan Carlson), Buy the movie
- Star Trek: First Contact, Lt. Commander Data (Brent Spiner), Lt. Commander Geordi La Forge (Levar Burton), Buy the movie)
- Star Trek: The Motion Picture, Spock (Leonard Nimoy), Dr. Leonard McCoy (DeForest Kelley), Cmdr. Montgomery Scott (James Doohan), Buy the movie
- Star Trek IV: The Voyage Home, Spock (Leonard Nimoy, Dr. Leonard McCoy (DeForest Kelley), Cmdr. Montgomery Scott (James Doohan), Buy the movie
- Straw Dogs David Summer (Dustin Hoffman, Buy the movie
- Superman, Jor-El (Marlon Brando), Buy the movie
- Terminator 2: Judgment Day, Miles Dyson (Joe Morton), Buy the movie
- Them! Dr. Harold Medford (Edmund Gwenn), Dr. Patricia Medford (Joan Weldon), Buy the movie
- The Thing Dr. Blair (Wilford Brimley), Dr. Copper (Richard Dysart), Buy the movie
- Titanic, Brock Lovett (Bill Paxton), Buy the movie
- Twister, Dr. Jo Harding (Helen Hunt), Bill Harding (Bill Paxton), Dr. Melissa Reeves (Jamie Gertz), other geophysicists, technicians. Villain: Dr. Jonas Miller (Cary Elwes), Buy the movie
- 2001: A Space Odyssey, Dr. Dave Bowman (Keir Dullea), Dr. Frank Poole (Gary Lockwood), Dr. Heywood Floyd (William Sylvester), Dr. Andrei Smyslov (Leonard Rossiter), Dr. Ralph Halvorsen (Robert Beatty), Dr. Bill Michaels (Sean Sullivan), Buy the movie
- 2010: The Year We Make Contact, Dr. Heywood Floyd (Roy Scheider), Dr. Walter Kurnow (John Lithgow), Dr. R. Chandra (Bob Balaban), Buy the movie
- Volcano, Dr. Amy Barnes (Anne Heche), Dr. Jaye Calder (Jacqueline Kim), Buy the movie
- War Games, Dr. John McKittrick (Dabney Coleman), Dr. Stephen Falkman (John Wood), Buy the movie
- The War of the Worlds (1953), Dr. Clayton Forrester (Gene Barry), Buy the movie
- Watchmen (2009), Dr. Manhattan (Billy Crudup)
- When Worlds Collide, Dr. Tony Drake (Peter Hansen), Dr. Cole Henderson (Larry Keating), Dr. George Fry (Stephen Chase), Buy the movie
- The World Is Not Enough, Christmas Jones (Denise Richards), R (John Cleese), and of course Q (Desmond Llewelyn), Buy the movie
- X Files, Dr. Dana Scully (Gillian Anderson)
- Young Frankenstein, Dr. Frankenstein (that's Fronkenstein!) (Gene Wilder), Buy the movie